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Thursday, September 17, 2026 will see the Buffalo Bills (1-0) take on the Detroit Lions (1-0) at New Highmark Stadium.
How to watch Detroit Lions vs. Buffalo Bills
Detroit vs. Buffalo odds
- Spread: Buffalo -3.5 (-109), Detroit +3.5 (-110)
- Favorite Moneyline: Buffalo -192
- Underdog Moneyline: Detroit +160
- Total: 53.5
- Total Over Odds: -109
- Total Under Odds: -110
Injury reports
Bills
No injuries listed
Lions
No injuries listed
Stats to know
- The Bills scored 28.3 points per game last season, 4.0 more than the Lions gave up.
- Buffalo’s offense held a 44.4-yard advantage in yards gained per game versus yards allowed by Detroit’s defense last year (376.3 to 331.9). Buffalo averaged 6.2 yards per play, while Detroit gave up 5.7.
- The Lions scored 28.3 points per game last season, 6.8 more than the Bills gave up.
- Buffalo’s defense surrendered 293.1 yards per game last season, 80.1 less than the 373.2 yards accumulated by Detroit’s offense. Detroit picked up 6.2 yards per play and Buffalo conceded 5.5.
This watch guide was created using technology provided by Data Skrive.
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Photo: Perry Knotts, Chris Unger / Getty Images
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